Winding along the Ohio River from Indiana, US-50 cuts east from Cincinnati across the hill-and-valley country of southern Ohio before finally crossing the Ohio River into West Virginia.

The 220 miles US-50 takes to cross the state are a fairly constant mix of upland forest and bottomland farms, with a single industrial district in the middle around Chillicothe, and a refreshing small college town, Athens, farther east.

Map of the Loneliest Road through Ohio.
Map of the Loneliest Road through Ohio.